Alzheimer's Miracle Drug Bexarotene Doesn't Hold Upward Every 2Nd Reported

Bexarotene, a cancer drug touted every bit a potential handling for Alzheimer’s disease, may non last the blockbuster remedy that scientist were hoping for.

Bob De Marco
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Co-authors Karthikeyan Veeraraghavalu and
Sangram Sisodia of the University of Chicago

Three teams of highly respected Alzheimer’s researchers failed to replicate what appeared to last breakthrough results for the handling of Alzheimer's affliction using existing cancer drug Targretin® (brand cite Bexarotene) (see below).

The master copy results, presented online Feb. 9, 2012, suggested that the drug bexarotene could apace contrary the buildup of beta amyloid plaques (Aβ) — a pathological hallmark of Alzheimer’s affliction — inward the brains of mice.

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• “Anecdotally, nosotros convey all heard that physicians are treating their Alzheimer's patients alongside bexarotene, a cancer drug alongside severe side effects,” said co-author Robert Vassar, PhD, professor of jail cellular telephone as well as molecular biological scientific discipline at Northwestern University Feinberg School of Medicine. “This practise should last ended immediately, given the failure of 3 independent question groups to replicate the plaque-lowering effects of bexarotene.”
• Bexarotene has never been tested every bit a handling for Alzheimer’s affliction inward humans, non fifty-fifty to gain upward one's heed the optimal dose or duration of treatment. This drug has meaning side effects, including major blood-lipid abnormalities, pancreatitis, liver purpose exam abnormalities, thyroid axis alterations, leucopenia, headaches, fatigue, weight gain, depression, nausea, vomiting, constipation as well as rash.

The 2 other technical comments came from question teams led past times Kevin Felsenstein, Todd Golde, David Borchelt as well as colleagues at the University of Florida as well as past times Bart DeStrooper as well as colleagues at the University of Leuven, Belgium.

This operate was supported past times the Cure Alzheimer’s Fund.

Additional authors include Karthikeyan Veeraraghavalu of the University of Chicago; +Rudy Tanzi , Can Zhang as well as Sean Miller of Massachusetts General Hospital; Jasmin K. Hefendehl as well as Mathias Jucker of the University of Tübingen; Tharinda W. Rajapaksha as well as Robert Vassar of Northwestern University Feinberg School of Medicine; as well as Jason Ulrich as well as David M. Holtzman from the Washington University School of Medicine.

To acquire to a greater extent than close Alzheimer's as well as dementia catch the Knowledge Base

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